The highest dose of a vitamin-D-receptor activator, paricalcitol, significantly reduced albuminuria in patients with diabetic nephropathy in the first randomized, placebo-controlled study to look at this type of agent in this setting. But large trials with hard end points will be needed to see whether the changes in this surrogate end point translate into morbidity and mortality benefits in this patient population and others, say the researchers.
Adding the calcimimetic agent cinacalcet to low-dose vitamin-D therapy might lead to less CAC than a flexible-dose regimen of vitamináD only in patients with chronic kidney disease and secondary hyperparathyroidism, according to a new study.
In a group of nearly 1000 subjects told they had low vitamin D at baseline, those who managed to up their levels over follow-up were significantly less likely to die or to suffer a combination of cardiovascular end points.
Two new studies looking at the link between use of vitamin D or blood levels of the supplement tilt in favor of the vitamin playing a role in preventing cardiovascular disease or helping improve CV risk factors. But more research is needed.
Another study has linked low levels of vitamin D to higher cardiovascular mortality. And it also suggests that deficiency of this vitamin may be an important factor in the black-white disparity in heart disease.
A new observational study shows an association between vitamin-D deficiency and cardiovascular disease and death. But definitive data are needed from randomized trials to confirm a beneficial role of this vitamin in CVD prevention, say researchers.
Study participants will be randomized to one of four groups: daily vitamin D (2000 IU) and fish oil (1 g); daily vitamin D and fish-oil placebo; daily vitamin-D placebo and fish oil; or daily vitamin-D placebo and fish-oil placebo and followed for five years.
Adolescents with low serum vitamin-D levels are much more likely to have hypertension, hyperglycemia, and metabolic syndrome, a large study showed; still, it is too early to recommend supplementation. (AHA 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.)
Another study has found that that low levels of vitamin D seem to be linked to an increased risk of death, this time in a nationally representative cohort. (Melamed ML et al. Arch Intern Med 2008; 168:1629-1637.)
The association was observed in a large, nationally representative sample and was present even after adjustment for multiple cardiovascular risk factors. (Melamed ML et al. Arterioscler Thromb Vasc Biol; published online before print April 16, 2008.)
Adults with low serum levels of vitamin D are more likely to have hypertension, diabetes, obesity, and high triglycerides. Investigators say it may be time to revisit public-health recommendations for vitamin-D intake. (Martins D et al. Arch Intern Med 2007; 167; 1159-1165.)
A new study suggests that women taking vitamin D supplements had a 31% reduction in risk of death from coronary heart disease compared to women who did not take supplements. Vitamin D, both a hormone and a vitamin, regulates calcium uptake in bones, but its absence may be somehow related to the appearance of calcium in arteries, the researchers speculate. (American Heart Association's Asia Pacific Scientific Forum.)