Clotblog with Dr Samuel Goldhaber

View all posts »

LIFENOX: No advantage of VTE prophylaxis in hospitalized medical service patients

Jan 13, 2012 09:20 EST


The surprising results of the LIFENOX trial—which failed to show an advantage of daily enoxaparin vs placebo to reduce mortality in the acute-care setting—challenge dogma. What explains these results?

See also:

Kakkar AK, Cimminiello C, Goldhaber SZ, et al. Low-molecular-weight heparin and mortality in acutely ill medical patients. N Engl J Med 2012; 365:2463-2472. Abstract.

Enoxaparin prophylaxis doesn't cut mortality in acute-care setting








Your comments
LIFENOX: No advantage of VTE prophylaxis in hospitalized medical service patients
# 1 of 1
January 23, 2012 09:54 (EST)
Maggie

How many additional research studies will be conducted to further investigate VTE prophylaxis benefits for specific populations?  Additionally, how will this affect the AHA's evidence-based measure?

 Thank you...


You must be a member (with full membership) to post a comment.
Already a member?
Enter your login information below:
 Remember me on this computer
Enjoy all the benefits of theheart.org

With full membership, you can check out our educational and editorial content, search the site, receive our newsletters, join discussions, download slides and much more.

Membership is free!

Who's Talking
Samuel Z Goldhaber, MD
Professor of Medicine
Harvard Medical School
Director, Venous Thromboembolism Research Group
Co-Director, Anticoagulation Management Service
Cardiovascular Division
Brigham and Women's Hospital
Boston, MA