Private practice with Dr Seth BilazarianView all posts »
Are you "JUPITER-ed" out??Feb 4, 2009 18:36 EST
The Jupiter trial is a large well conducted study which has been exhaustively covered on theheart.org as well as other websites. The study has had very little impact on clinical practice now 3 months after presentation and publication of the data. There is little discussion amongst patients or primary care physicians about the use of CRP for the Jupiter to find patient subset.
The trial has validated CRP as a useful biomarker for patient’s in an intermediate risk range and having this "objective" criteria may help convince some patient’s to except statin therapy white otherwise have been reticent
This trial seems to demonstrate safety and efficacy of rosuvastatin that puts it solidly in the family of the other statin medications and gives me more confidence to use this therapy especially in patients who need 50% or more LDL lowering to achieve a desired goal.
Guidelines for application of this trial and CRP in general are eagarly awaited . (last updated in 2003)
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. N Engl J Med. 2008 Nov 20;359(21):2195-207.
Expanding the Orbit of Primary Precention: Moving beyond Jupiter. Hlatky, MA. N Engl J Med. 2008 Nov 20; 359(21): 2280-2282.