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Complex trait genomics, or why common gene variants don't fully explain diseaseJul 26, 2010 16:00 EDT
A landmark new study by Dr Robert A Hegele's team at the University of Western Ontario explores common and rare variants for hypertriglyceridemia and shows that a combination of multiple rare variants of common genes can help to explain heritability of disease.
What are your thoughts on this study and the role of complex trait genomics in cardiovascular medicine?
Johansen Christopher T, Wang Jian, Lanktree Matthew B, et al. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nature Genetics. 25 July 2010. Abstract.