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Creating cardiac diseases in a dish using pluripotent stem cellsFeb 21, 2011 12:24 EST
Fascinating research using induced pluripotent stem cells has effectively allowed researchers to create "diseases in a dish". The medical implications are exciting and far-reaching: creating a means for researchers to recapitulate diseases and design appropriate therapies that match biologically.
What are your thoughts on this new trend for cardiovascular medicine?
Itzhaki I, Maizels L, Huber I, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature. 2011 Jan 16. Abstract.
Moretti A, Bellin M, Welling A, et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med. 2010 Oct 7;363(15):1397-409. Abstract.
Yazawa M, Hsueh B, Pasca AM, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature. 2011. 2011 Feb 9. Abstract.