I read this fascinating article in full. While I am excited about the pharmacogenomic implications, the fishing for atherosclerosis-related genes in this individual, to inform personal risk, then to correlate that with a stress test made no sense to me - why not perform some atheroma imaging instead to view the disease itself? ie either coronary artery calcification, MRI, or carotid ultrasonography with total plaque area determination.  We are looking for upstream markers to determine downstream risk - instead of looking at the downstream process itself, already accreting plaque on the arterial wall.