TopologView all posts »
Statins and diabetes: A hard look at the dataMar 1, 2012 17:25 EST
The data are clear: in primary prevention, when comparing the benefit in preventing heart attack, stroke, and death vs the risk of diabetes, the trade-off is very slim—and the dangers, very real.
Preiss D, Seshasai SR, Welsh P, et al. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA 2011; 305:2556-2564. Abstract.
Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359:2195-207. Abstract.
Sattar N, Preiss D, Murray H, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010; 375:735-742. Abstract.
Heart Protection Study Collaborative Group. MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo controlled trial. Lancet 2002; 60:7-22. Abstract.