Acute Coronary Syndrome

Prevention

India attempts to impose world's biggest smoking ban

1 COMMENT - Oct 3, 2008 11:30 EDT

The Indian government appears to have heeded the warnings of medical experts highlighting the immense problem of smoking in the country, with the introduction this week of a nationwide ban on smoking in public places.

New Delhi, India - India is attempting to impose the world's largest smoking ban, with a nationwide edict prohibiting smoking in all public places that came into effect yesterday, to commemorate Gandhi's birthday [1,2].

The initiative is supported by a massive public-awareness campaign, with pamphlets being given out and articles and advertisements in all major Indian newspapers [3]. For the first few days, smokers caught flouting the ban will be given a warning; thereafter they will be fined 200 rupees (approximately $5), more than the average person's daily wage. Read full article »

Inside: Acute Coronary Syndrome

Accredited educational programs, supported by industry, developed by theheart.org

Acute Coronary Syndrome

Focus on bleeding

Sep 23, 2008 09:17 EDT

Bleeding in ACS patients has been associated with increased adverse cardiac events and negative patient outcomes. Join Dr Deepak Bhatt and panelists Drs Ehtisham Mahmud and Gabriel Steg as they discuss the treatment options and strategies to reduce bleeding in patients with ACS.

Acute Coronary Syndrome

The FellowShip series: What is a bleed and what does it mean in clinical practice?

Sep 9, 2008 17:00 EDT

Bleeding in ACS patients has been associated with increased adverse cardiac events and negative patient outcomes. Join Drs Gilles Montalescot and Johanne Silvain as they discuss a case of bleeding and review treatment strategies to improve outcomes and minimize adverse events for these patients.

Acute Coronary Syndrome

Antiplatelet/anticoagulant Treatment Recommendations in the STEMI Guidelines

1 COMMENT - Sep 15, 2008 09:56 EDT

Antiplatelet therapy and anticoagulant therapy are the foundations for the treatment of acute coronary syndromes (ACS). Join Dr Eric Bates and panelists Drs Gabriel Steg, Robert Storey and Steen Dalby Kristensen as they discuss new guideline recommendations for the use of antiplatelet therapy and anticoagulant therapy in patients experiencing an acute coronary syndrome (ACS).

Acute Coronary Syndrome

The Science and Medicine of Circulatory Dysfunction and Acute Pressure Syndromes

Aug 18, 2008 09:37 EDT

An investigator and clinical scholar, Dr. Christopher Granger, MD, the program chairman, and his distinguished colleagues illuminate the emerging threats and clinical challenges cardiologists face when managing patients who present with, or undergo, acute, severe, serious, precipitous, and/or life-threatening elevations in systemic blood pressure.

Clinical cardiology

Antiplatelet Therapy: When the Evidence Meets the Experience

Oct 1, 2008 10:15 EDT

The optimal management of patients with ACS is an ever-evolving process; clinical experience and practice often outpace guidelines. Watch Drs Bohm, Camm, Fox, Mehta, and Connolly address the state-of-the-art management of ACS and the role of antiplatelets in ACS and beyond.

Acute Coronary Syndrome

Prevention of Arterial Thrombosis, a Review of Agents in Development

Sep 15, 2008 09:33 EDT

Join Drs Mahaffey, Hylek, Wallentin, and Weitz as they discuss the mechanisms by which various antithrombotic therapies target the coagulation cascade, the efficacy and safety of the currently available agents, and promising results from clinical trials of novel agents.

Clinical cardiology

Thienopyridines in PCI: The lowdown on loading doses

Jun 23, 2008 11:00 EDT

Current guidelines for thienopyridines in PCI note the lack of RCT data for higher loading doses. Read Dr Wang's lowdown on loading doses, including recent presentations from the 2008 SCAI-ACCi2 meeting. Then watch Drs Mehta and Mehran discuss where CURRENT-OASIS-7 will fit in.

Antiplatelet therapies

Safety and efficacy: Balancing the risk

1 COMMENT - Jun 19, 2008 09:37 EDT

In light of recent data, how do you balance the risk and benefit of current treatment options? Answer 3 short polling questions in the Antiplatelet Therapies section and see what your colleagues do.

Acute Coronary Syndrome

Optimising outcomes in acute coronary syndromes: role of new approaches to platelet inhibition

5 COMMENTS - Jun 3, 2008 14:22 EDT

Balancing antithrombotic efficacy with risk of bleeding: Join our international panel of experts, Steen Husted, José Carlos Nicolau, Sunil Rao and Robert Storey as they review the mechanisms of platelet activation and emerging evidence from ongoing studies to novel antiplatelet therapies.

Acute Coronary Syndrome

Stem cells for AMI: New review finds same old story

Oct 7, 2008 19:00 EDT

A familiar message has emerged from a new review of stem-cell therapy for acute MI—a moderate improvement was seen, but much more research is needed. (Martin-Rendon E et al. Cochrane Database Syst Rev 2008; 4: CD006536. Eur Heart J 2008; 29:1807-1818.)

Prevention

Societies confront GI risks of antiplatelets, NSAIDs in consensus document

1 COMMENT - Oct 7, 2008 10:00 EDT

It addresses a common clinical problem for which there is little clinical-trial-quality data for guidance and gives a starring role to proton-pump inhibitors in treating GI ulcers and bleeding and, in high-risk groups, in their prevention. (Bhatt DL et al. J Am Coll Cardiol; Circulation; published online before print October 3, 2008.)

Interventional/Surgery

Elective PCI possible without "safety net" of anticoagulation

4 COMMENTS - Oct 6, 2008 17:00 EDT

Low-risk patients with uncomplicated lesions can have elective PCI safely performed using dual antiplatelet therapy without systemic anticoagulation, according to a new randomized study. An accompanying editorial begs to differ, however. (Stabile E et al. J Am Coll Cardiol 2008; 1293-1298.)

Interventional/Surgery

Oct 1, 2008 17:45 EDT

Should the ACC/AHA guidelines for the management of STEMI patients extend the acceptable PCI-related delay to as long as 120 minutes? A group of Danish researchers thinks so, but Dr Elliott Antman, who cochaired the writing committee of those guidelines, disagrees. (Terkelsen CJ et al. Antman E. J Am Coll Cardiol 2008; 52:1211-1215, 1216-1221.)

Acute Coronary Syndrome

New study finds type of HRT is key with regard to MI risk

Oct 1, 2008 13:45 EDT

Important new information on HRT and the risk of MI has emerged from a Danish observational study, which finds that the type of HRT used could be key when it comes to the likelihood of a heart attack. (Lokkegaard E et al. Eur Heart J; published online before print September 30, 2008.)

Clinical cardiology

Routinely screen for clinical depression in CHD, AHA formally recommends

Sep 30, 2008 09:45 EDT

Providers should take the opportunity in any setting in which they see CHD patients, according to a "science advisory" from the organization, which acknowledges a lack of direct evidence that such efforts will improve the patients' clinical outcomes. (Lichtman JH et al. Circulation 2008; published online before print September 29, 2008.)

Prevention

Eating dark chocolate reduces CRP

1 COMMENT - Sep 29, 2008 13:30 EDT

A new Italian study has shown, for the first time, that consuming moderate amounts of dark chocolate can significantly reduce CRP levels. (di Giuseppe R et al. J Nutr 2008; 138:1939-1945.)

Interventional/Surgery

FDA once again postpones decision on prasugrel

Sep 29, 2008 09:00 EDT

Acute Coronary Syndrome

Enrollment stopped in NIH-funded trial studying chelation therapy for treatment of CAD

Sep 24, 2008 19:00 EDT

UPDATED WITH INTERVIEW // Enrollment into the Trial to Assess Chelation Therapy, a five-year, $30-million, National Institutes of Health-funded clinical study, has been "temporarily and voluntarily stopped." No word yet from investigators as to why enrollment into the controversial study is on hold.

Interventional/Surgery

Two-year Massachusetts registry results support mortality benefit of DES in AMI

Sep 24, 2008 17:00 EDT

Whether the benefits are due to restenosis reduction, the additional months of dual antiplatelet therapy, or other effects of the DES itself are unclear, authors note. (Mauri L et al. N Engl J Med 2008; 359:1330-1342.)

Acute Coronary Syndrome

Poor and Medicaid recipients with MI have longest prehospital delays

Sep 24, 2008 13:45 EDT

New research shows that those with Medicaid insurance and those living in low-income neighborhoods are less likely than their better-off counterparts to get to the hospital quickly after an acute MI. This adds to prior studies that have shown that race, sex, age, and comorbid conditions can influence the time taken to get to the hospital following AMI. (Foraker RE et al. Arch Intern Med 2008; 168:1874-1879.)

Arrhythmia/EP

Out-of-hospital cardiac arrest: Location is all

Sep 23, 2008 16:00 EDT

A new analysis of out-of-hospital cardiac arrest in 10 areas in North America has found a fivefold difference in survival rates. The researchers say an estimated 15 000 premature deaths could be prevented each year if survival could be increased in those places not performing well. A related article contends that to try to improve outcomes, attention should be focused on those most likely to survive. (Nichol G et al. Sasson C et al. JAMA 20082; 300:1423-1431, 1432-1438.)

Brain/Kidney/Peripheral

Passive smoking ups risk of PAD by 50%

Sep 22, 2008 16:00 EDT

Chinese researchers have reported, for the first time, a link between exposure to passive smoke and peripheral arterial disease in a cohort of women who have never smoked. They call for urgent public-health measures to protect individuals from secondhand smoke. (He Y et al. Circulation: published online before print September 22, 2008.)

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