Thrombosis
Aspirin unneeded with anticoagulation/clopidogrel after MI, PCI in AF
9 COMMENT S - Jun 6, 2013 17:00 EDT
A large national cohort study somewhat confirms what the WOEST trial suggested: that an oral anticoagulant plus one antiplatelet is sufficient in patients with multiple indications for antithrombotic therapy.

Copenhagen, Denmark - The addition of one antiplatelet agent to oral anticoagulation is sufficient in patients with atrial fibrillation (AF) who experience an MI or PCI, and the antiplatelet agent probably should be clopidogrel instead of aspirin, concluded a study of >12 000 patients from nationwide registries in Denmark [1].

Despite the common recommendation for triple antithrombotic therapy in patients with multiple indications for antithrombotic therapy, which would have added aspirin into the mix, "Our data suggest that triple-therapy-management regimens might be replaced with oral anticoagulation and clopidogrel without any additional risk of recurrent thrombotic events and a lower risk of bleeding," according to the authors, led by Dr Morten Lamberts (Copenhagen University Hospital Gentofte, Hellerup, Denmark).
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