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PLATO, CURRENT-OASIS 7, and further analyses of PPIs and thienopyridines; read Dr Prasad's review of recent data presented at ESC; and watch presentations by Drs Mehran, O'Donoghue, Storey, and Wiviott.
PLATO, CURRENT-OASIS 7, COGENT, recent meetings have seen some blockbuster presentations in the area of antiplatelet/antithrombotic therapy. What is your response to these data? Answer our 4 short polling questions and learn your peers' responses.
PLATO, the ESC late-breaking trial, compared a novel direct-acting reversible P2Y12 antagonist with clopidogrel in ACS patients undergoing PCI. Dr. Keith Fox leads a discussion with the PI, Dr. Lars Wallentin, and Dr. Deepak Bhatt.
With the recent approval of a third-generation thienopyridine, choice of agent can be added to the list of considerations in the management of ACS patients, as well as the appropriate timing and dosing of thienopyridine. Using some case vignettes, Dr. King leads a discussion with Drs. Bhatt and Steg on their clinical decision-making.
Antiplatelet therapy is key for the prevention of secondary events in ACS patients. Dr. Ardissino introduces a series of brief presentations by Drs. Angiolillo, Fernánadez-Avilés, Montalescot, and Neumann on the optimal use of antiplatelets in ACS patients undergoing PCI, including those with diabetes and those at high bleeding risk.
How will the prasugrel approval and the upcoming PLATO and CURRENT-OASIS 7 trials affect antiplatelet options for ACS patients undergoing PCI? Read a summary of the latest data, with expert input from Drs. Ardissino and Montalescot.
A patient suffers a STEMI after exploratory laparotomy for suspected gastrinoma; their surgeon insists that no anticoagulation be given. How would you treat? Dr. Rao presents such a complicated case to Dr. Montalescot.
From SOLACI 2009 in Rio de Janeiro. Dr. Mahmud hears how Dr. Feres interprets the data on antiplatelet/antithrombin strategies for his practice in Brazil.
HORIZONS-AMI has influenced US practice; after TRITON-TIMI 38, the potential role of prasugrel is a hot topic. How has Latin America responded to these data? Recorded at SOLACI 2009, Dr. Mahmud has an information exchange on contemporary antiplatelet management with two of Argentina's leading interventionalists, Drs. Grinfeld and Londero.
Early-ACS, HORIZONS-AMI, On-TIME 2... How do you use GP IIb/IIIa inhibitors in contemporary practice? Given the continued uncertainty regarding the optimal duration of dual antiplatelet therapy, what do you do for AF patients on warfarin who need stents? Answer our 3 short polling questions and learn your peers' responses.
After EARLY-ACS and HORIZONS-AMI, the utility of routine GP IIb/IIIa inhibitors in contemporary management of ACS patients has been challenged. Studies of prehospital and pre-angiography administration have yielded mixed results, largely reflecting different trial designs. Dr. Gershlick aims to clarify matters with Drs. Hamm and Mehran.
Patients with diabetes have more reactive platelets and are also more likely to have a diminished response to antiplatelet therapy. Dr. Angiolillo presents Dr. Storey with a case illustrating issues in the management of antiplatelet therapy in an ACS patient with diabetes.
Carriers of certain CYP genetic variants have lower levels of clopidogrel's active metabolite and experience higher rates of MACE. Could genotyping help optimize antiplatelet therapy? Common PPIs also inhibit CYP enzymes and may impair clopidogrel efficacy. Dr. Topol discusses recent data on these topics with Drs. Montalescot, Sabatine, and Simon.
Are you concerned about the effects of genetics and proton pump inhibitors on antiplatelet efficacy? How will you incorporate novel agents? Answer 4 short polling questions and learn what your colleagues do.
The adjunctive pharmacologic regimen for the management of patients with STEMI is influenced by local practice and preferences in addition to emerging clinical study data. Join Drs. Fox, Hamm, and Mehran as they discuss the implications of some of last year's top trials including HORIZONS-AMI, TRITON-TIMI 38, On-TIME 2, FINESSE and BRAVE. Then hear Dr. Ohman's take on facilitated PCI.
On February 3, 2009, the FDA's Cardiovascular and Renal Drugs Advisory Committee unanimously voted to recommend approval of the novel thienopyridine prasugrel for use in ACS patients undergoing PCI. Drs. Nissen, Ohman, Kandzari, Topol, and Steg each give their take on the likely implications for clinical practice and remaining issues of concern in the optimal management of patients with ACS.
Data on new antiplatelet therapies that may help optimize antiplatelet therapy and decrease morbidity and mortality in patients with acute coronary syndromes (ACS) is emerging. Join Drs Steg, Montalescot, Morrow, and Windecker as they highlight these data and treatment strategies to effectively manage ACS patients.
Antiplatelet agents, such as aspirin, the thienopyridines, and the glycoprotein IIb/IIIa inhibitors, have proven to be effective in reducing the incidence of adverse events that are associated with plaque rupture in patients following PCI. Join our experts as they discuss the current issues and controversies related to the overall management of these patients and the use of antiplatelet therapy.
The International Diabetes Federation estimates that diabetes accounts for approximately 6% of total global mortality. Some 50% of diabetes-associated deaths can be directly attributed to cardiovascular disease. Join our expert panel, Drs Bhatt, Morrow, Van de Werf, and Wiviott, as the review the new data on early detection and interventions for these patients
Stent thrombosis remains a serious complication of stent implantation despite the use of antiplatelet therapy. Join Drs Ohman and Jolicoeur for a case presentation of a challenging stent thrombosis case.
Data has shown that oral antiplatelet therapy management practices vary widely. Answer 3 short polling questions in the Antiplatelet Therapies section and see what your colleagues do.
The management of patients with drug-eluting stents who are undergoing noncardiac surgery can be challenging. Join Dr Mahmud and panelists Drs Eagle and Kandzari as they review a difficult case.
New data has shown that anticoagulant/antiplatet therapy reduce the incidence of bleeding and improve bleeding and improve outcomes in patients undergoing PCI. Join Dr Ohman and panelists Drs Mehran, Bates, and Montalescot as they discuss the treatment options and as they discuss strategies to implement these new data.
Both the US and the European Guidelines for the Management of STEMI have recently been revised to reflect new data specific to the management and treatment of STEMI patients. Join Dr E Magnus Ohman and panelists Drs Robert Harrington, Robert Storey and Jean-Pierre Bassand as they discuss the differences between the US and the European STEMI Guidelines as well as the optimal management goals for patients with STEMI.
With several new oral antiplatelet agents looming large on the horizon, don't miss this unique opportunity to hear the experts share new clinical data and analysis!
Take a second to answer a series of new polling questions in the Antiplatelet Therapies section. Let us know your experience with balancing risk and benefit in light of all current treatment options.
Acknowledgements
CME provider: Medscape.
The Antiplatelet Therapies clinical theme is supported by an independent educational grant from Daiichi Sankyo, Inc. and Eli Lilly & Co. and Medtronic.
Steering committee
The steering committee members are active in overseeing the development and direction of this educational series.