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heartbriefs
Sen Grassley questions top medical schools about ghostwriting
Nov 20, 2009 13:15 EST
As part of his mission to see more financial transparency in medicine, Sen Grassley has asked eight top US medical schools about their policies on ghostwriting.
Acute Coronary Syndromes
Oral anticoagulants REDEEMed? Daily dabigatran "safe" with dual antiplatelets after MI
Nov 19, 2009 11:00 EST
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors.
News
EFFECT: Public reporting of hospital performance improves quality of care?
Nov 19, 2009 10:00 EST
Publicly released report cards based on hospital performance did not result in a measurably greater systemwide improvement in two composite AMI or CHF process-of-care indicators in a Canadian study. But they did appear to stimulate some important changes in delivery of care that could have led to some better outcomes.
Thrombosis Risk
Ticagrelor effects unraveled in new phase 2 trials
Nov 18, 2009 15:00 EST
New and unique phase 2 data add to the growing body of evidence explaining the pharmacologic effects of the new antiplatelet agent ticagrelor.
Imaging
CT-STAT: CT angiography rules out CAD faster and cheaper than standard care
6 COMMENTS - Nov 18, 2009 13:45 EST
The use of coronary CT angiography in the emergency room can successfully triage at-risk chest-pain patients and can do so faster and less expensively than standard diagnostic testing.
Acute Coronary Syndromes
ACC/AHA focused update of guidelines for STEMI, PCI
9 COMMENTS - Nov 18, 2009 09:00 EST
The latest evidence for the treatment of STEMI and PCI has been incorporated into a fast-track update of US guidelines. But questions remain about the quality of some of the evidence informing the guidelines and about the composition of the writing committees.
Acute Coronary Syndromes
Cangrelor in CHAMPION: What went wrong?
2 COMMENTS - Nov 16, 2009 15:15 EST
Discussion is abounding on why cangrelor did not show benefit over clopidogrel despite the fact that it did inhibit platelet activity more effectively.
Acute Coronary Syndromes
Good news continues for ticagrelor in PLATO STEMI subanalysis
1 COMMENT - Nov 15, 2009 19:30 EST
Ticagrelor, an investigational antiplatelet agent, may become a new standard of care for the management of patients with STEMI heading for primary PCI, said the lead investigator of the STEMI subset of the PLATO trial. Reporting the new findings here today, he said they were consistent with the overall PLATO results.
Thrombosis Risk
POPULARity contest: For platelet function assays, what works, what doesn't
Nov 15, 2009 14:15 EST
None of the eight platelet assays studied were able to predict bleeding, but four of the eight, based on ADP-induced platelet aggregation, produced results that correlated with adverse CV outcomes. By contrast, four tests that use shear-stress-induced adhesion-based methods were not predictive.
Interventional/Surgery
PEPCAD-3: Paclitaxel-coated-balloon/stent system misses mark in de novo coronary lesions
Nov 15, 2009 10:30 EST
Inflation of the paclitaxel-delivering balloon followed by a bare-metal stent failed a randomized noninferiority test against the Cypher sirolimus-eluting stent in previously untreated coronary lesions.
Acute Coronary Syndromes
CHAMPION: Negative trials but some positive angles for cangrelor?
2 COMMENTS - Nov 15, 2009 08:00 EST
Although neither CHAMPION-PCI nor CHAMPION-PLATFORM showed significant reductions in the primary end point with this new IV antiplatelet agent, some positive effects were seen, suggesting that the drug may yet have a future.
Medscape Medical News
SGR repair bill failure could cool physician support for healthcare reform
Nov 12, 2009 15:00 EST
Now that the US House of Representatives has passed a healthcare reform bill, organized medicine anticipates another vote—possibly next week—on a second bill that would rewrite Medicare's controversial sustainable-growth-rate formula for physician reimbursement.
News
What's going to be hot at AHA 2009?
2 COMMENTS - Nov 11, 2009 09:00 EST
Anticipation is building for full trial results from ARBITER 6-HALTS, plus a better understanding of what went wrong with cangrelor in the CHAMPION trials. Also in the lineup are updates from PLATO, RE-LY, ALLHAT, BARI 2D, STICH, CASCADE, POPULAR, HEARTMATE II, and many more. Indeed, this year's "late-breaking" sessions include more than 30 trials over five days.
Clinical cardiology
Walking speed predicts CV mortality in older people
4 COMMENTS - Nov 10, 2009 19:01 EST
Fast walkers should find themselves less likely to succumb to cardiovascular death, according to a new French study in older adults. Measuring general fitness in this way could easily be incorporated into a general global assessment of cardiovascular risk, say the researchers.
Acute Coronary Syndromes
Clopidogrel effects in men vs women
Nov 10, 2009 16:15 EST
A new meta-analysis has suggested that clopidogrel reduces cardiovascular events and increases bleeding in both men and women, without significant differences between the sexes.
Imaging
DE-MRI shows which myocardial injury is irreversible
Nov 9, 2009 16:00 EST
Distinguishing myocardial scarring with MRI may help predict LV functional recovery.
Acute Coronary Syndromes
Latest European and US STEMI guidelines compared and contrasted
7 COMMENTS - Nov 6, 2009 17:15 EST
The latest recommendations for the treatment of ST-elevation MI issued by American cardiology associations and the European Society of Cardiology are compared and contrasted in a new paper.
Interventional/Surgery
VELETI in print: Plaque sealing of SVGs a strategy "ahead of its time"?
Nov 4, 2009 15:30 EST
The imaging study was the first to show that stenting a non-flow-limiting stenosis of an SVG may help slow or halt the accelerated atherosclerosis that takes place in these vessels. An accompanying editorial cautions that the study does little more than "infer a trend toward anatomic benefit."
Imaging
CAC scoring plus SPECT provide long and short view of cardiac risk
7 COMMENTS - Nov 3, 2009 17:00 EST
UPDATED // An 1126-patient trial shows that SPECT and CAC scoring imaging tests are independent and complementary predictors of short- and long-term cardiac risk, respectively.
Interventional/Surgery
US updates advice on perioperative beta-blocker use in noncardiac surgery
6 COMMENTS - Nov 3, 2009 14:30 EST
A US update on the perioperative use of beta blockers for noncardiac surgery is, says the lead author, "similar" to recent European guidance on this issue.
Imaging
Imaging study shows plaque regression with niacin vs placebo
19 COMMENTS - Oct 30, 2009 16:00 EDT
Just weeks before ARBITER-HALTS 6 results come out at AHA 2009, an MRI study suggests that niacin is better than placebo in statin-treated patients with low HDL, at least for reducing carotid wall area. Experts say they'd also like to see insights into niacin effects on lipid-rich plaque volumes—the more commonly seen end point with MRI.
Acute Coronary Syndromes
First trial of viral-derived protein agent shows promise as anti-inflammatory ACS therapy
Oct 29, 2009 11:45 EDT
Inflammatory responses contribute to coronary plaque rupture, thrombosis, and vascular occlusion. Some viruses have proteins that interfere with these inflammatory responses. Researchers have identified a viral-derived protein that may eventually be an anti-inflammatory treatment for coronary syndromes.
Acute Coronary Syndromes
Sex differences in changing MI prevalence, mortality challenge conventional wisdom
Oct 29, 2009 10:30 EDT
Two well-known observational registries highlight such changes in women and men over a decade or more: Do women younger than 55 still have an advantage over men in the same age group?
Acute Coronary Syndromes
Bariatric surgery fails to reduce risk of MI long term
1 COMMENT - Oct 28, 2009 14:30 EDT
After a median follow-up of 12 years, MI rates were essentially the same among those treated with surgery and those who received conventional care for weight loss.
Acute Coronary Syndromes
Contrary to common belief, women feel same heart-attack symptoms as men
4 COMMENTS - Oct 27, 2009 14:30 EDT
Women and men have the same rates of chest pain and other classic symptoms during ACS, although women are more likely to experience some other symptoms such as jaw and neck pain.

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Acute Coronary Syndromes
Antiplatelet Therapy: Autumn Poll
Oct 26, 2009 08:59 EDT
PLATO, CURRENT-OASIS 7, COGENT, recent meetings have seen some blockbuster presentations in the area of antiplatelet/antithrombotic therapy. What is your response to these data? Answer our 4 short polling questions and learn your peers' responses.
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Acute Coronary Syndromes
Antiplatelet Therapy for ACS Patients Intended for PCI: How Are the Data Adding Up?
Oct 19, 2009 17:51 EDT
Join Drs. Cannon, Gupta, Schampaert, and Le May as they discuss how data stemming from recent clinical trials are adding up for ACS patients in Canada intended for PCI. They review how clinical decision-making based on efficacy, safety, and patient profile is changing in light of antiplatelet therapies that are currently available and those that may be available in the near future.