Hypertension
MRI evidence of plaque progression in aliskiren-treated patients
1 COMMENT - May 22, 2013 08:00 EDT
Although the totality of the evidence did show a significantly increased risk of plaque progression with aliskiren, the increase was driven by a change in aortic plaque among individuals treated with it in combination with an ACE inhibitor or angiotensin-receptor blocker.

San Francisco, CA - A small study in patients with established cardiovascular disease treated with aliskiren (Tekturna, Novartis) suggests the direct renin inhibitor increases aortic atherosclerosis as measured by MRI [1]. Although the totality of the evidence did show a significantly increased risk of plaque progression with aliskiren, the increase was driven by a change in aortic plaque among individuals treated with it in combination with an ACE inhibitor or angiotensin-receptor blocker (ARB).
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