At the ESH meeting, two experts took opposing views concerning the current war on salt. One believes the current salt/sodium targets were simply pulled out of a hat and have no scientific basis at all, while the other believes the targets are necessary to help start a low-sodium environment for future generations, lowering their potential risks of hypertension and cardiovascular disease.
Daytime blood pressure measured by 24-hour ambulatory blood-pressure monitoring was reduced by 8.9/3.7 mm Hg, report investigators. The data suggest that the addition of spironolactone might be beneficial in this hard-to-treat patient population already receiving multiple antihypertensive medications, they add.
The committee says the benefits of diclofenac exceed the known risks and that physicians should take the same precautions to minimize thromboembolic risk as they do with patients treated with selective COX-2 inhibitors.
At least 23 deaths and 600 adverse-event reports have been collected by Health Canada since 2007. The agency says it still believes the benefits of the drospirenone-containing birth-control pills outweigh the risks, although VTE risk is higher with these pills than with earlier-generation ones.
European, Canadian, and Australian regulators all approved both the 110-mg and 150-mg doses studied in the RE-LY trial, while the FDA approved only the higher dose. A new analysis is once again calling this decision into question.
A large national cohort study somewhat confirms what the WOEST trial suggested: that an oral anticoagulant plus one antiplatelet is sufficient in patients with multiple indications for antithrombotic therapy.
Patients carrying the SNP, which is located in the CYP2C9 gene, require a significantly lower stable dose of warfarin than do those without the variant, say researchers. The addition of the SNP also improved the International Warfarin Pharmacogenetics Consortium treatment algorithm by 21%.
A new proof-of-concept study has shown for the first time that the investigational monoclonal antibody lowers LDL cholesterol in this rare inherited disorder, but only in patients who have residual LDL-receptor activity, and not in those with none.
The study shows once again that kids with high blood pressure are likely to remain hypertensive as adults, but in a glimmer of hope, young people who got their blood pressure under control did not appear to have the same atherosclerotic progression seen among those who remained or became hypertensive.
According to the European Atherosclerosis Society, familial hypercholesterolemia is woefully underdiagnosed and undertreated. The society has recently completed a new consensus paper offering some advice.
To heartwire, a couple of doctors expressed caution and curiosity about the extraordinary results, including the 50% reduction in mortality, and say they need to see the data published in a peer-reviewed journal before jumping on the CoQ10 bandwagon. The Q-SYMBIO investigators say they are planning to submit the study for publication.
Patients treated with the drug, known only as BAY94-8862 at the moment, had a significantly lower risk of hyperkalemia than patients treated with spironolactone, as well as a lower risk of worsening renal failure. The drug also reduced BNP levels as much as spironolactone.
Continuing aspirin is usually acceptable, but there is less guidance on how to manage other antithrombotic meds during surgery or other procedures in patients with cerebrovascular disease, according to the American Academy of Neurology document.