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Lipid/Metabolic
No increased atherosclerotic-plaque burden in cops and firefighters
Mar 14, 2010 08:45 EDT
The atherosclerotic-plaque burden among cops and firefighters is no higher than in a cohort of age-matched controls, suggesting that something else, possibly increased emotional and physical stress, is causing the increased risk of on-the-job cardiac-related events.

Atlanta, GA - The stereotypical image of the cop and the doughnut is challenged this week with new data from a group of researchers showing that police officers, as well as firefighters, do not have greater burdens of atherosclerosis compared with age-matched controls [1]. Read full article »

Inside: Clinical cardiology
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Clinical cardiology
Safety of Implantable Defibrillators: Lead Fractures
Apr 17, 2009 11:41 EDT
Recent data among heart patients have suggested that approximately 2.3% of patients with a defected implant lead attached to their defibrillator will experience lead fracture within 30 months of having the device implanted. What are your thoughts and is this happening in your clinical practice?
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Hypertension
ACE inhibitor/ARBs still used in pregnancy despite teratogenicity
Mar 19, 2010 14:15 EDT
New research from the UK has found that doctors are still prescribing ACE inhibitors and angiotensin-receptor blockers in women of child-bearing age, despite evidence that they are teratogenic. Reasons include a lack of awareness of the issue among GPs and obstetricians and ambiguity in hypertension guidelines, says the researcher.
Prevention
Death, CVD risk declines in people who "normalize" vitamin-D levels
4 COMMENTS - Mar 18, 2010 17:00 EDT
In a group of nearly 1000 subjects told they had low vitamin D at baseline, those who managed to up their levels over follow-up were significantly less likely to die or to suffer a combination of cardiovascular end points.
Hypertension
New drug, similar to omapatrilat, impressive in hypertension
Mar 18, 2010 16:00 EDT
A new BP-lowering drug that acts in a similar way to omapatrilat—an agent that never quite made it to the market—has shown promise in a preliminary trial. Crucially, this dual inhibiting agent, named LCZ696, blocks angiotensin II rather than angiotensin-converting enzyme; there was no indication of angioedema in the study.
Medscape Medical News
Erectile dysfunction a red flag for mortality, cardiovascular events
Mar 17, 2010 13:45 EDT
New findings suggest erectile dysfunction is a marker for increased risk of death and heart attacks in men with heart disease.
Interventional/Surgery
PLATO CABG analysis confuses cardiologists
6 COMMENTS - Mar 16, 2010 17:15 EDT
Cardiologists here at the ACC meeting were confused by a new analysis of PLATO, this time in ACS patients who subsequently underwent CABG surgery. Those in the ticagrelor group were 50% less likely to die, despite the fact that there was no difference in bleeding or MIs between these patients and those who got clopidogrel. The investigator admitted he didn't have the answers, and further analyses "are ongoing."
Thrombosis
Warfarin genotyping reduces hospitalizations
Mar 16, 2010 16:00 EDT
Although there was a suggestion that some of the effect could have simply been due to more attention being paid to the patients, most agree that any intervention that helps warfarin control is worthwhile.
Hypertension
Is BP variability a stronger determinant of CV outcomes than mean pressure?
1 COMMENT - Mar 16, 2010 09:45 EDT
A host of new analyses published in the Lancet journals, some of which were also reported at the ACC meeting, suggest that variability in blood pressure is a much stronger determinant of both stroke and coronary disease outcome than average blood pressure. And calcium-channel blockers have the strongest effect of all antihypertensives on reducing BP variability, say the researchers.
Interventional/Surgery
Cardiologists voice concern on FDA clopidogrel warning
3 COMMENTS - Mar 16, 2010 09:00 EDT
Several experts have questioned why the FDA has issued a warning about poor metabolizers of clopidogrel when there are no firm data about what to do for these patients.
Arrhythmia/EP
New factor Xa inhibitor betrixaban safe in phase 2 AF trial
Mar 15, 2010 14:45 EDT
A novel oral factor Xa inhibitor, betrixaban, was safe and well tolerated when compared with warfarin in a phase 2 trial in patients with AF. Along with other new anticoagulants, this could represent an advance on warfarin, but betrixaban first needs to be evaluated in a much larger phase 3 trial, said the lead researcher.
Arrhythmia/EP
Faster CONNECTions: Remote monitoring reduces event-to-decision time
Mar 15, 2010 13:30 EDT
Remote monitoring of ICDs reduces the time from clinical events to a clinical decision by about three weeks, on average, results of the CONNECT study of Medtronic's CareLink ICD remote-monitoring system show.
Thrombosis
Optimal dual antiplatelet duration in REAL-LATE, ZEST-LATE: Too little, too soon
3 COMMENTS - Mar 15, 2010 10:30 EDT
UPDATED // Cardiologists of every stripe are eager for any new information on just how long their patients should be taking dual antiplatelet therapy after receiving a drug-eluting stent. But the REAL-LATE/ZEST-LATE analysis seems to provide more questions than answers. The question everyone now seems to be asking now is, so what?
The Heart of a Woman
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Editorial Programs
The Cardiology Show
ACC 2010 Review from Atlanta: INVEST, ACCORD, EVEREST II, and NAVIGATOR
Mar 17, 2010 16:25 EDT
Dr Valentin Fuster sits down with Drs Peter Berger, Anne Curtis, Tim Gardner, Tony Gershlick, Harlan Krumholz, Darren McGuire, Ileana Piña, and Rita Redberg to discuss the lessons learned at the ACC 2010 Scientific Sessions, including why lower may not be better for blood pressure, why preventing diabetes does not necessarily reduce cardiovascular risk, and the future of the mitral-valve clip.
Editorial series
Informed consent, clinical research, and patient care
1 COMMENT - Mar 11, 2010 14:20 EST
Does informed consent protect patients or shield researchers? Join the debate with Dr Bob Harrington and his guests Drs Deepak Bhatt and Harvey White.
Editorial series
Women in cardiology: Is gender an issue?
5 COMMENTS - Mar 4, 2010 10:15 EST
Do gender perceptions affect the way female physicians are treated in cardiology? Drs Melissa Walton-Shirley, Judith Hochman, Suzanne Oparil, and Lynne Warner Stevenson tackle this important question.
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