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heartbriefs
Sen Grassley questions top medical schools about ghostwriting
Nov 20, 2009 13:15 EST
As part of his mission to see more financial transparency in medicine, Sen Grassley has asked eight top US medical schools about their policies on ghostwriting.
News
EFFECT: Public reporting of hospital performance improves quality of care?
Nov 19, 2009 10:00 EST
Publicly released report cards based on hospital performance did not result in a measurably greater systemwide improvement in two composite AMI or CHF process-of-care indicators in a Canadian study. But they did appear to stimulate some important changes in delivery of care that could have led to some better outcomes.
Thrombosis Risk
Ticagrelor effects unraveled in new phase 2 trials
Nov 18, 2009 15:00 EST
New and unique phase 2 data add to the growing body of evidence explaining the pharmacologic effects of the new antiplatelet agent ticagrelor.
Acute Coronary Syndromes
ACC/AHA focused update of guidelines for STEMI, PCI
9 COMMENTS - Nov 18, 2009 09:00 EST
The latest evidence for the treatment of STEMI and PCI has been incorporated into a fast-track update of US guidelines. But questions remain about the quality of some of the evidence informing the guidelines and about the composition of the writing committees.
Medscape Medical News
RE-LY: Post hoc analysis confirms benefit of dabigatran relative to warfarin at all INR levels
Nov 17, 2009 16:30 EST
A new analysis confirms that regardless of INR control achieved across participating centers, dabigatran remained noninferior at the lower dose and superior at the higher dose to warfarin for prevention of stroke and systemic embolism.
Clinical cardiology
Cardiologists shocked by new FDA alert on clopidogrel-PPI interaction
Nov 17, 2009 15:45 EST
The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction.
Medscape Medical News
Anthracycline cardiotoxicity appears limited in breast cancer in the short term
Nov 17, 2009 11:15 EST
No significant incidence of short-term cardiac toxicity was observed in breast-cancer patients on dose-dense anthracycline regimens, but longer-term follow-up is needed.
Interventional/Surgery
POPE: No benefit of diclofenac on pericardial effusion
Nov 17, 2009 10:00 EST
Mean pericardial effusion grade postcardiac surgery was not reduced with 14 days of treatment with the NSAID.
Brain/Kidney/Peripheral
Bypassing the blues: How simple collaborative care can help tackle depression after CABG surgery
Nov 16, 2009 18:45 EST
Depression after coronary artery bypass surgery is often overlooked by physicians but is associated with worse outcomes. A new US study illustrates a simple telephone-based approach to tackle this, with nurses encouraging patients to seek help from their primary-care doctors and providing ongoing feedback and review.
Arrhythmia/EP
RECORD AF: Better success with rhythm control, but no difference in outcomes
Nov 16, 2009 17:00 EST
New registry data presented this week showed that cardiologists are more likely to select rhythm control over rate control for the treatment of atrial fibrillation, and this strategy is more likely to lead to successful treatment of AF than the rate-control-based approach. Both strategies are equivalent in terms of their effect on clinical outcomes.
Clinical cardiology
Plasma renin activity associated with cardiovascular events and mortality in HOPE
1 COMMENT - Nov 16, 2009 14:45 EST
Patients with elevated baseline plasma renin activity levels had a twofold increased risk of total or cardiovascular mortality compared with those with low levels, and the strength of the association persisted after multiple adjustments, including the HOPE score, CRP, and BNP.
Thrombosis Risk
POPULARity contest: For platelet function assays, what works, what doesn't
Nov 15, 2009 14:15 EST
None of the eight platelet assays studied were able to predict bleeding, but four of the eight, based on ADP-induced platelet aggregation, produced results that correlated with adverse CV outcomes. By contrast, four tests that use shear-stress-induced adhesion-based methods were not predictive.
Prevention
Canadian confusion: Primary-care docs lack knowledge of CVD risk factors, prevention
8 COMMENTS - Nov 15, 2009 09:00 EST
Family doctors and general practitioners in Canada are confused about cardiovascular risk assessment in primary prevention, a new survey reveals.
Medscape Medical News
SGR repair bill failure could cool physician support for healthcare reform
Nov 12, 2009 15:00 EST
Now that the US House of Representatives has passed a healthcare reform bill, organized medicine anticipates another vote—possibly next week—on a second bill that would rewrite Medicare's controversial sustainable-growth-rate formula for physician reimbursement.
Interventional/Surgery
DES fractures occur more often than thought
4 COMMENTS - Nov 12, 2009 13:15 EST
A new postmortem study using high-resolution imaging has found that fractures in drug-eluting stents may be more common than thought. However, the majority of such fractures appear to be low-grade and silent, with likely few clinical implications, say the researchers.
Lipid/Metabolic
Total- and HDL-cholesterol levels, not triglycerides, predict vascular risk
Nov 12, 2009 10:00 EST
Clinicians can simplify their existing risk-assessment tools by measuring either total- and HDL-cholesterol levels or apolipoproteins, and this assessment can effectively be done in patients who did not fast before the test.
News
What's going to be hot at AHA 2009?
2 COMMENTS - Nov 11, 2009 09:00 EST
Anticipation is building for full trial results from ARBITER 6-HALTS, plus a better understanding of what went wrong with cangrelor in the CHAMPION trials. Also in the lineup are updates from PLATO, RE-LY, ALLHAT, BARI 2D, STICH, CASCADE, POPULAR, HEARTMATE II, and many more. Indeed, this year's "late-breaking" sessions include more than 30 trials over five days.
Clinical cardiology
Walking speed predicts CV mortality in older people
4 COMMENTS - Nov 10, 2009 19:01 EST
Fast walkers should find themselves less likely to succumb to cardiovascular death, according to a new French study in older adults. Measuring general fitness in this way could easily be incorporated into a general global assessment of cardiovascular risk, say the researchers.
Prevention
No benefits of aspirin for primary prevention in diabetics, meta-analysis suggests
6 COMMENTS - Nov 10, 2009 17:15 EST
Most guideline documents recommend aspirin for primary prevention in people with diabetes, but a new meta-analysis has found no benefit of the widely used drug across a range of different cardiovascular end points. The results speak to the need for dedicated randomized trials, investigators say.
Medscape Medical News
Echocardiographic evidence of PAH often doesn't trigger referral to a specialist
Nov 10, 2009 11:00 EST
Only one in four patients with echocardiographic evidence of pulmonary arterial hypertension is being referred for further evaluation.
Hypertension
Ambrisentan effective long-term for pulmonary arterial hypertension
1 COMMENT - Nov 9, 2009 17:00 EST
New data from the extension phase of two pivotal trials of the endothelin-receptor antagonist ambrisentan support its use as part of a long-term strategy for the treatment of pulmonary arterial hypertension.
Medscape Medical News
US House passes healthcare reform bill
Nov 9, 2009 10:00 EST
In the face of near-unanimous Republican opposition and a last-ditch effort to change the bill, the US House of Representatives voted in favor of legislation to overhaul the nation's healthcare system.
Murmurs
Interventional cardiologist Donald Baim dies
19 COMMENTS - Nov 6, 2009 18:22 EST
UPDATED // Interventional cardiologist Dr Donald Baim, chief medical and scientific officer at Boston Scientific, has died.
heartbriefs
Medicaid access to smoking cessation falls short
Nov 5, 2009 17:30 EST
A national survey shows that although the majority of state Medicaid programs offer coverage for some form of tobacco-dependence treatment, most fall far short of a stated mandate to provide unrestricted access to approved therapies.
Medscape Medical News
Low-cholesterol/cancer studies should "dispel lingering doubts" of causal link
Nov 5, 2009 14:15 EST
Two new papers should help put to rest concerns that low serum cholesterol levels may increase cancer risk.

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Clinical cardiology
Safety of Implantable Defibrillators: Lead Fractures
Apr 17, 2009 11:41 EDT
Recent data among heart patients have suggested that approximately 2.3% of patients with a defected implant lead attached to their defibrillator will experience lead fracture within 30 months of having the device implanted. What are your thoughts and is this happening in your clinical practice?
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Clinical cardiology
Heart Rate-Lowering Therapy in Canada: Reviewing Target Populations and Clinical Outcomes
Nov 12, 2009 09:52 EST
Join Dr. Tardif as he discusses the latest clinical data addressing heart rate-lowering therapy in patients with stable coronary heart disease and left ventricular systolic dysfunction. The role of heart rate-lowering therapy and target populations are reviewed, as well as the next steps required for application to Canadian medical practice.