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Variations on chromosome 4q25 are associated with atrial fibrillation (AF). If you had a family history of AF, would you be tested? Dr. Christopher Granger who has such a personal history underwent testing. He discusses the role of genetics in the management of patients with or at risk for AF.
The 2008 AHA meeting included a special session on "Personalized Genomics: Ready for Prime Time?" Read Dr Wang's article on recent genetic findings in CAD, AF and HF while Drs Ballantyne, Granger, Herrington, Mega and Topol address related AHA presentations and the clinical utility of genetic data in CVD management.
Variations in the VKORC1 and CYP2C9 genes alter warfarin metabolism. In August 2007, the FDA label for warfarin was updated to highlight genetic testing to predict warfarin response. David Herrington addresses the utility of genetic testing to more rapidly optimize warfarin dosing.
Genetic variations have been associated with an increased risk for type 2 diabetes (T2D) – a condition strongly influenced by lifestyle factors. In a literal case of personalized medicine, Dr Geoffrey Ginsburg discusses the role of genetic testing in the assessment of patients, including himself, at risk for T2D.
Acknowledgements
CME provider: Medscape.
The Genetics and CV Disease theme is supported by an independent educational grant from deCODE Genetics.
Steering committee
The steering committee members are active in overseeing the development and direction of this educational series.