Acute Coronary Syndromes
SWITCH III: Bivalirudin is as safe as heparin after fondaparinux in PCI patients
Feb 7, 2012 12:30 EST
Recent studies have shown that ACS patients on fondaparinux prior to PCI should switch to another anticoagulant prior to the procedure to avoid thrombus. The SWITCH III trial compares bivalirudin and unfractionated heparin in a small group of these patients.

Washington, DC - The direct thrombin inhibitor bivalirudin (Angiomax, the Medicines Company) is as safe as standard-dose unfractionated heparin in acute coronary syndrome patients treated with upstream fondaparinux (Arixtra, GlaxoSmithKline) prior to angiography followed by possible PCI, a small trial shows.

Dr Ron Waksman (Washington Hospital Center, DC) presented results from the 100-patient SWITCH III safety trial here at CRT 2012, the Cardiovascular Research Technologies conference. The trial randomized patients with non-ST-elevation acute coronary syndromes taking the factor Xa inhibitor fondaparinux to switch to either bivalirudin or unfractionated heparin about 24 hours before undergoing angiography.
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