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PLATO, CURRENT-OASIS 7, and further analyses of PPIs and thienopyridines; read Dr Prasad's review of recent data presented at ESC; and watch presentations by Drs Mehran, O'Donoghue, Storey, and Wiviott.
In the US, each year over 1.4 million people will be hospitalized for unstable angina (UA) and non-ST-segment-elevation myocardial infarction (NSTEMI). Multiple antiplatelet agents have been developed to interfere with or inhibit the specific pathways of platelet activation and aggregation that lead to the development of UA and NSTEMI. Join Drs Newby, Popma, and Wiviot as they discuss.
The PARTNER and PAVIS trials of transcatheter aortic valve implementation will include inoperable or very high-surgical-risk patients. In Europe, where the devices have been approved for a few years, the technology is being expanded to lesser-risk patients. Interventionalist Dr Jeffrey Popma discusses the selection of patients with surgeon Dr Mathew Williams.
Atrial fibrillation is associated with a high risk for stroke, myocardial infarction, heart failure, and death. How does blockade of the renin-angiotensin system affect patient outcomes? Join our international panel of experts, Drs Camm, Connolly, Crijns, and Granger, as they discuss the ESC 09 hotline results of the ACTIVE-I trial.
Dr. Dean Kereiakes leads an international panel of experts, Drs. Meredith, Banning, and Hermiller, as they discuss fascinating developments in stent and polymer technology and design their "dream stent."
Read Dr. Jonathan Piccini's review of prevention of stroke in AF and how the newly released results of clinical trials of novel antithrombotic agents will reduce the risk for stroke. Then listen to our international panel of experts, Drs. Camm, Granger, Prystowsky, and Yusuf, as they give their take on new data released at ESC 2009.
How do drug-eluting stents compare? Our panel of experts, Drs. Stone, Kereiakes, Serruys, and Windecker discuss the late-breaking trials at TCT 2009 of DES vs DES.
PLATO, the ESC late-breaking trial, compared a novel direct-acting reversible P2Y12 antagonist with clopidogrel in ACS patients undergoing PCI. Dr. Keith Fox leads a discussion with the PI, Dr. Lars Wallentin, and Dr. Deepak Bhatt.
What effect does doubling the dose of clopidogrel have on outcomes in patients undergoing PCI? Dr. Salim Yusuf discusses the results of the CURRENT-OASIS 7 trial and other new data on antithrombotic agents.
Dr. Ileana Piña discusses the design and outcomes of the MADIT-CRT trial with Drs. Moss and Estes, and how these new data may benefit patients with heart failure.
An older patient appearing obviously fatigued and "worn out" presents in the office complaining of heaviness in the chest, and shortness of breath especially with any type of exercise. Not your typical angina patient, or is it? How do you go about working up this patient to make the right diagnosis? Drs. Pepine and Wenger discuss the approach to patients with ischemia and treatment considerations.
Since BARI, CABG has been the gold standard for patients with diabetes and multivessel disease. However, SYNTAX suggests an increasing role for PCI and BARI 2D highlights the importance of optimal medical therapy. Dr. Boden leads a multidisciplinary discussion with Drs. Holmes and Taggart.
Evidence-based therapies, both pharmacologic and devices are well documented in published guidelines, but are they followed and implemented in practice? Is there a treatment gap? Is it all about education or the lack thereof? Drs. Yancy, Abraham, and Pfeffer confer on evidence from recent registries and trials.
Join our international panel of experts, Drs. Lip, Halperin, Weitz, Ezekowitz, Wallentin, and Connolly as they present late-breaking results of the RE-LY trial.
Despite improvements in the treatment of HF, morbidity and mortality remain a pressing public health issue. Disappointing and controversial results with positive inotropic agents have driven the search for new mechanisms and approaches to improve cardiac performance. Drs. Greenberg, Felker, McMurray, and Pfeffer explore these new possibilities.
With the recent approval of a third-generation thienopyridine, choice of agent can be added to the list of considerations in the management of ACS patients, as well as the appropriate timing and dosing of thienopyridine. Using some case vignettes, Dr. King leads a discussion with Drs. Bhatt and Steg on their clinical decision-making.
AF is sometimes considered a benign or nuisance condition. However, it is vital that it is recognized as a harbinger of underlying cardiovascular disease, and that it is diagnosed early and treated appropriately. Join Drs. Kirchhof, Dorian, Marrouche, and Steg as they discuss strategies to reduce the complications of AF.
Patients presenting with STEMI represent a high-risk population. Thrombotic and bleeding complications contribute to mortality in these patients. Join Drs. Steg, Hamm, Hill, and Mehran as they discuss best practices for the treatment of STEMI patients with a focus on preventing bleeding complications.
Antiplatelet therapy is key for the prevention of secondary events in ACS patients. Dr. Ardissino introduces a series of brief presentations by Drs. Angiolillo, Fernánadez-Avilés, Montalescot, and Neumann on the optimal use of antiplatelets in ACS patients undergoing PCI, including those with diabetes and those at high bleeding risk.
How will the prasugrel approval and the upcoming PLATO and CURRENT-OASIS 7 trials affect antiplatelet options for ACS patients undergoing PCI? Read a summary of the latest data, with expert input from Drs. Ardissino and Montalescot.
Does early intervention with CRT-D slow the progression of heart failure? Watch as Dr. David Cannom interviews Drs. Camm, Hlatky, Klein, Moss and Page, and gets their expert opinions on late-breaking clinical trial data released at ESC 09 and how it will affect patient care.
Join Drs Giles, Elliott, Mason and White as they discuss a new approach to preservation of NO offered by the cyclooxygenase-inhibiting nitric oxide donating (CINOD) drugs, which may have an important role in treating arthritis patients with hypertension.
A patient suffers a STEMI after exploratory laparotomy for suspected gastrinoma; their surgeon insists that no anticoagulation be given. How would you treat? Dr. Rao presents such a complicated case to Dr. Montalescot.